Additional Resources for the Single Organism Paradigm.
| Head for your favorite search engine and do a search on the following
terms.
Pregnancy "fetal allograft" ; + "fetal semi allograft" ; + "fetal semiallograft" ; + "fetal semiallogenic" . You might also try dropping the 'semi' if you feel enterprising. These are a small part of the results using GOOGLE _____________________________________________________________________
Immunoresponses during pregnancy and in the perinatal period Project leader: Professor Rigmor Austgulen Normal pregnancy: Due to its paternal antigens, the fetus may be regarded as a semiallograft in the maternal organism. Successful reproduction is dependent on both local (intrauterine) and systemic immunosuppressive mechanism from the beginning (implantation) until the end (delivery) of pregnancy. Source ___________________________________________________________
A Review: Suppressed Cell -Mediated Immunity and Monocyte and Natural Killer Cell Activity Follow mg Allogeneic Immunization of Women with Spontaneous Recurrent Abortion Treatment for women with frequent SRA's is very limited because the cause, or causes, has not yet been pinpointed. Due to the apparent close interactions between the mother and fetus - considered a semiallograft -this system provides an excellent therapeutic target for SRA's. It has been previously shown that pretransplant blood transfusions during tissue grafting enhances graft survival (7). Also, end-stage renal disease patients treated with blood transfusions show a pronounced decrease in Th-1 responses with an increase in Th-2 responses (8). It is hypothesized, then, that immunizing women through blood transfusions could assist in fetal survival if the same responses are induced. Source
Maternal - Fetal Interactions Histologically, the fetus is an allograft (actually a semiallograft since half of its antigenic makeup comes from the mother). Why is this graft tolerated when a skin graft from the child to the mother in later life would be rejected if the immune system were not suppressed? Source
In natural pregnancies, the embryo/fetus is genetically different from the mother because of carrying a complement of paternal genes. This situation comprises one of the major paradoxes of contemporary immunology, raising the question of how the genetically different embryo/fetus and mother co-exist during gestation. Human pregnancy, where cells from the implanted blastocyst migrate in massive numbers into the decidualized maternal endometrium, presents the greatest challenge. Over the course of the past two decades, many conditions providing protection to the human fetal semiallograft have been identified. These are provided by both the mother and by the extraembryonic tissues of the embryo/fetus. They include soluble substances such as prostaglandins, progesterone and anti-inflammatory cytokines that include transforming growth factor-p and interleukin-l 0. All of these are produced in the female reproductive tract during pregnancy and are present in the uterus and placenta. Remarkably, the placenta and extraplacental membranes themselves have evolved an array of powerful protective mechanisms. To prevent destruction by maternal complement-fixing antibodies to paternally-derived and fetal antigens, the placenta exhibits high levels of the cell surface regulatory proteins that interrupt the complement cascade. Recent experiments in knockout mice show clearly that in the absence of appropriate complement regulatory proteins, ...... Source (note-PDF file)
Recurrent Miscarriage (Pregnancy Loss)
Immunologic Factors One of the most interesting functions of the placenta is the regulation of the maternal immune response such that the fetal semi-allograft is tolerated during pregnancy. Trophoblasts are presumed to be essential to this phenomenon because they lie at the maternal–fetal interface, where they are in direct contact with cells of the maternal immune system. Trophoblasts do not express classic major-histocompatibility-complex (MHC) class II molecules.66 Surprisingly, cytotrophoblasts express more HLA-G,............... Source
mAbs.
During pregnancy, the fetus can be considered as a semi- allogenic
allograft. However, the fetus is tolerated by the
0review
As mentioned above the placenta consists of tissues derived from both the mother and the embryo, the fetal part being derived from the embryonic membranes and the maternal part from the uterine wall. (It is this boundary between the maternal and fetal tissues that necessitates the immunologic role of the placenta as the embryo is normally semi- allogeneic to the mother.) This initially small area of fetomaternal apposition is enormously increased during pregnancy as the placenta develops by folding and refolding while it proliferates in parallel with the fetus in order to provide the fetus with the nutrients it needs to develop normally and to remove the waste products the fetus produces. Source See also Williams Obstetrics 1997, page 20, for a further discussion of the semiallogenic fetal graft. Those who have read my posts in the past have seen my reference to the apple tree as a close analogy of the reproductive process in humans where the blossom eventually leads to the new seed bearer when the apple falls from the tree yet during the full reproductive phase the apple is a part of the tree. It could be sensibly argued that the POC is not a real graft to the body of the woman (or pregnancy unit) because there was never a time when it was not a part of her body even when the trophoblasts suppress HLA, (human leukocyte antigens) to prevent rejection. To claim it is not a part of her body is to deny biological reality. Just for the purpose of giving some historicity to this paradigm and to support my claim that it is also an ancient concept - and recognizing this has no scientific validity - I would note that the Jewish religion regards the fetus as the equivelant of a limb. During the debate on the so called "Unborn Victims of Violence" act reference was made to the Talmudic interpretation of the relationship between the woman and developing offspring. I quote: In Judaism, the fetus is viewed as part of the woman’s body and not a separate human being maintaining equal rights. Women are commanded to care for the health and well being of their bodies above all else.See Also The Legal Status of the Embryo/FetusAs you can see the "single organism" paradigm is an ancient one, much older than the dual organism one which has only come into real vogue in the past 30 years or so, and has done so to fulfill an agenda. When you look at the multiple quotes above it is obvious that this is not simply a concept I have dreamed up but one that has a solid and accepted scientific basis. The more ambitious reader might be interested in checking these book Suggestions also: Biology As Ideology : The Doctrine of DNA by Richard C. Lewontin Book Description: Following in the fashion of Stephen Jay Gould and Peter Medawar, one of the world's leading scientists examines how "pure science" is in fact shaped and guided by social and political needs and assumptions.
Another book suggestion: The Making of the Unborn Patient: A Social Anatomy of Fetal Surgery by Monica J. Casper, From the description: Casper tracks the steps that have made fetuses into patients, from the development of fetal transfusions for prevention of Rh disease in the 1960s through advances in techniques of prenatal diagnosis to operations on pregnant women ..................
Eileen |